Estimation of relative bioavailability of lead in soil and soil-like materials using young swine

被引:153
作者
Casteel, Stan W.
Weis, Christopher P.
Henningsen, Gerry M.
Brattin, William J.
机构
[1] US EPA, Natl Enforcement Invest Ctr, Denver Fed Ctr, Denver, CO 80225 USA
[2] Univ Missouri, Coll Vet Med, Vet Med Diagnost Lab, Columbia, MO USA
[3] H&H Sci Serv LLP, Evansville, IN USA
[4] Syracuse Res Corp, Denver, CO USA
关键词
lead; RBA; relative bioavailability; swine;
D O I
10.1289/ehp.8852
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In this article we summarize the results of a series of studies that measured the relative bioavailability (RBA) of lead in a variety of soil and soil-like test materials. Reference material (Ph acetate) or Pb-contaminated soils were administered orally to juvenile swine twice a day for 15 days. Blood samples were collected from each animal at multiple times during the course of the study, and samples of liver, kidney, and bone were collected at sacrifice. All samples were analyzed for Pb. We estimated the RBA of a test material by fitting mathematical models to the dose-response curves for each measurement end point and finding the ratio of doses that gave equal responses. The final RBA for a test material is the simple average of the four end point-specific RBA values. Results from 19 different test materials reveal a wide range of RBA values across different exposure materials, ranging from 6 to 105%. This variability in RBA between different samples highlights the importance of reliable RBA data to help improve risk assessments for Ph in soil. Although the RBA value for a sample depends on the relative amounts of the different chemical and physical forms of Ph present, data are not yet adequate to allow reliable quantitative predictions, of RBA from chemical speciation data alone.
引用
收藏
页码:1162 / 1171
页数:10
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