Amyloid fibrils from organic solutions of an amphiphilic dipeptide

被引：6

作者：

Casanovas, Jordi ^{[1
]}

Mayans, Enric ^{[2
,3
]}

Diaz, Angelica ^{[2
,3
]}

Gil, Ana M. ^{[4
]}

Jimenez, Ana I. ^{[4
]}

Cativiela, Carlos ^{[4
]}

Puiggali, Jordi ^{[2
,3
,5
]}

Aleman, Carlos ^{[2
,3
,5
]}

机构：

[1] Univ Lleida, Escola Politecn Super, Dept Quim, C Jaume II 69, E-25001 Lleida, Spain

[2] Univ Politecn Cataluna, EEBE, Dept Engn Quim, C Eduard Maristany 10-14,Ed 12, Barcelona 08019, Spain

[3] Univ Politecn Cataluna, EEBE, Barcelona Res Ctr Multiscale Sci & Engn, C Eduard Maristany 10-14,Ed 12, Barcelona 08019, Spain

[4] Univ Zaragoza, CSIC, Dept Quim Organ, ISQCH, E-50009 Zaragoza, Spain

[5] Barcelona Inst Sci & Technol, Inst Bioengn Catalonia IBEC, Baldiri Reixac 10-12, Barcelona 08028, Spain

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 59期

关键词：

DIPHENYLALANINE PEPTIDE; PROTEIN AGGREGATION; SELF; SOLVENT; MEMBRANES; HYDROGEL; WATER;

D O I：

10.1039/c9cc04139g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Non-hydrated organic solutions of a diphenylalanine amphiphile blocked at the C-terminus with a fluorenylmethyl ester and stabilized at the N-terminus with a trifluoroacetate have been used to prepare amyloid fibrils. The solvent used to prepare the stock solution together with the co-solvent added enables regulation of the characteristics of the fibrils, which is important for their use in technological applications.

引用

页码：8556 / 8559

页数：4

共 42 条

[1] Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment [J].