Synthesis of kanamycin A analogs containing 6-amino-3-oxa-2,3,4,6-tetradeoxy-D- and -L-glycero-hexopyranose

被引：3

作者：

Kuwahara, R ^{[1
]}

Tsuchiya, T ^{[1
]}

机构：

[1] INST BIOORGAN CHEM,NAKAHARA KU,KAWASAKI,KANAGAWA,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1996年 / 286卷

关键词：

kanamycin analog; 6-Azido-3-oxa-2,3,3,6-tetradeoxy-glycero-hexopyranose;

D O I：

10.1016/0008-6215(96)00051-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Azido-3-oxa-2,3,4,6-tetradeoxy-D- and -L-glycero-hexopyranoses were synthesized in five steps from (2S)- and (2R)1,2-O-isopropylideneglycerols, respectively. After conversion into the corresponding ethyl l-thioglycosides, each was condensed with a protected derivative of 6-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl)-2-deoxystreptamine (16). Deprotection and reduction of the azido group of the condensation products gave the title compounds.

引用

页码：107 / 122

页数：16

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