Improvement of drug delivery by hyperthermia treatment using magnetic cubic cobalt ferrite nanoparticles

被引：105
|
作者：
Dey, Chaitali [1 ]
Baishya, Kaushik [2 ]
Ghosh, Arup [2 ,3 ]
Goswami, Madhuri Mandal [2 ]
Ghosh, Ajay [4 ]
Mandal, Kalyan [2 ]
机构：
[1] Ctr Res Nanosci & Nanotechnol, Block JD 2,Sect 3, Kolkata 700106, India
[2] SN Bose Natl Ctr Basic Sci, Block JD,Sect 3, Kolkata 700106, India
[3] Indian Inst Sci Educ & Res IISER Pune, Dept Phys, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
[4] Univ Calcutta, Dept Appl Opt & Photon, Block JD 2,Sect 3, Kolkata 700106, India
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2017年 / 427卷
关键词：
Magnetic nanoparticles; Cobalt ferrite; Magnetic hyperthermia; Drug release; FE3O4 HOLLOW SPHERES; TOXICITY; SYSTEMS;
D O I：
10.1016/j.jmmm.2016.11.024
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this study, we report a novel synthesis method, characterization and application of a new class of ferromagnetic cubic cobalt ferrite magnetic nanoparticles (MNPs) for hyperthermia therapy and temperature triggered drug release. The MNPs are characterized by XRD, TEM, FESEM, AC magnetic hysteresis and VSM. These MNPs were coated with folic acid and loaded with an anticancer drug. The drug release studies were done at two different temperatures (37 degrees C and 44 degrees C) with progress of time. It was found that higher release of drug took place at elevated temperature (44 degrees C). We have developed a temperature sensitive drug delivery system which releases the heat sensitive drug selectively as the particles are heated up under AC magnetic field and controlled release is possible by changing the external AC magnetic field.
引用
收藏
页码：168 / 174
页数：7
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