Increased levels of serum neopterin in attention deficit/hyperactivity disorder (ADHD)

被引：13

作者：

Ceylan, Mehmet Fatih ^{[1
]}

Uneri, Ozden Sukran ^{[2
]}

Guney, Esra ^{[2
]}

Ergin, Merve ^{[3
]}

Alisik, Murat ^{[3
]}

Goker, Zeynep ^{[2
]}

Dinc, Gulser Senses ^{[2
]}

Kara, Fatma Karaca ^{[4
]}

Erel, Ozcan ^{[3
]}

机构：

[1] Yildirim Beyazit Univ, Fac Med, Child & Adolescent Psychiat Dept, Ankara, Turkey

[2] Ankara Pediat & Pediat Hematol Oncol Training & R, Child & Adolescent Psychiat Dept, Ankara, Turkey

[3] Yildirim Beyazit Univ, Fac Med, Dept Med Biochem, Ankara, Turkey

[4] Ankara Pediat & Pediat Hematol Oncol Training & R, Dept Med Biochem, Ankara, Turkey

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 273卷 / 1-2期

关键词：

Attention deficit/hyperactivity disorder; ADHD; Neopterin; Cellular immunity; CHILDREN; INFECTION; SPECTRUM; ASSOCIATION; PREGNANCY; MARKERS; STRESS;

D O I：

10.1016/j.jneuroim.2014.06.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attention deficit/hyperactivity disorder (ADHD) is the most frequently occurring neuropsychiatric disorder in childhood with an etiology that is not fully understood. A number of reviews that have addressed the neurobiology of ADHD have focused on imaging and genetics. Relatively little attention has been given to factors/mechanisms involved in the brain dysfunction. We suggest that changes in cellular immunity may be involved. Neopterin is a good indicator of cellular immunity, and we evaluated serum levels of neopterin in patients with ADHD. The study group consisted of 49 patients with ADHD. An age- and gender-matched control group was composed of 31 healthy subjects. Venous blood samples were collected, and the levels of neopterin were measured. The levels of neopterin were significantly higher in ADHD than in the comparison subjects. Cellular immunity may have a role in the etiopathogenesis of ADHD. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：111 / 114

页数：4

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