Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity

被引：19

作者：

Tang, Liying ^{[1
,2
]}

Wang, Zhuju ^{[1
]}

Wu, Hongwei ^{[1
]}

Yokosuka, Akihito ^{[2
]}

Mimaki, Yoshihiro ^{[2
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[2] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Med Pharmacognosy, Hachioji, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 2014年 / 107卷

关键词：

Dracaena thalioides; Agavaceae; Steroidal glycosides; Spirostanol glycosides; Cytotoxic activity; HL-60; cells; Apoptosis; SAPONINS; CONSTITUENTS;

D O I：

10.1016/j.phytochem.2014.07.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1,3-6, and 8-18 showed cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38 mu M and induced apoptosis in HL-60 cells. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：102 / 110

页数：9

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