Polymeric Drug Delivery of Platinum-Based Anticancer Agents

被引：112
作者：
Haxton, Katherine J. [1 ,2 ]
Burt, Helen M. [1 ]
机构：
[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC, Canada
[2] Keele Univ, Sch Phys & Geog Sci, Keele ST5 5BG, Staffs, England
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 98卷 / 07期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
polymeric drug delivery systems; polymers; dendrimers; nanoparticles; biodegradable polymers; microparticles; macromolecular drug delivery; macromolecular prodrugs; micelle; PLGA-MPEG NANOPARTICLES; METAL COMPLEX MICELLE; ANTITUMOR-ACTIVITY; CLINICAL PHARMACOKINETICS; CISPLATIN DELIVERY; ESCHERICHIA-COLI; PROSTATE-CANCER; BLOCK-COPOLYMER; CELL-DIVISION; PHASE-I;
D O I：
10.1002/jps.21611
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Platinum-based anticancer agents such as cisplatin and carboplatin are in widespread clinical use but associated with many side effects. Improving the delivery of cytotoxic platinum compounds may lead to reduced side effects and achieve greater efficacy at lower doses. Polymer-based therapeutics have been investigated as potential drug delivery vehicles for platinum-based drugs. Against a background of the chemistry and pharmacology of cytotoxic platinum compounds, this review discusses the formation and properties of platinum-polymer complexes, dendrimers, micelles, and microparticulates. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:2299-2316, 2009
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页码：2299 / 2316
页数：18
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