Risk factors for increased duration of untreated psychosis. Results from the FACE-SZ dataset

被引：19

作者：

Fond, G. ^{[4
,11
]}

Boyer, L. ^{[11
,15
]}

Andrianarisoa, M. ^{[4
,11
,14
,20
]}

Godin, O. ^{[11
,19
]}

Brunel, L. ^{[4
,11
,14
,20
]}

Bulzacka, E. ^{[4
,11
,14
,20
]}

Coulon, N. ^{[11
]}

Llorca, P. M. ^{[3
,11
]}

Berna, F. ^{[2
,11
,17
]}

Aouizerate, B. ^{[1
,11
,13
,16
]}

D'Amato, T. ^{[5
,6
,11
]}

Dubertret, C. ^{[6
,8
,11
]}

Dubreucq, J. ^{[7
,8
,11
]}

Faget, C. ^{[7
,9
,11
]}

Gabayet, F. ^{[7
,9
,11
]}

Mallet, J. ^{[7
,8
,9
,11
]}

Misdrahi, D. ^{[8
,11
,12
]}

Rey, R. ^{[6
,11
,16
,18
]}

Richieri, R. ^{[11
]}

Roux, P. ^{[9
,11
]}

Passerieux, C. ^{[10
,11
]}

Schandrin, A. ^{[5
,10
,11
]}

Tronche, A. M. ^{[3
,5
,11
]}

Vidailhet, P. ^{[2
,3
,11
]}

Leboyer, M. A. ^{[11
,17
]}

Schurhoff, F. ^{[4
,11
,14
,20
]}

Andrianarisoa, M. ^{[4
,11
,14
,20
]}

Aouizerate, B. ^{[1
,11
,13
,16
]}

Berna, F. ^{[2
,11
,17
]}

Blanc, O. ^{[3
,11
]}

Brunel, L. ^{[4
,11
,14
,20
]}

Bulzacka, E. ^{[4
,11
,14
,20
]}

Capdevielle, D. ^{[5
,11
]}

Chereau-Boudet, I. ^{[3
,11
]}

Chesnoy-Servanin, G. ^{[6
,11
]}

Danion, J. M. ^{[2
,11
]}

D'Amato, T. ^{[5
,6
,11
]}

Deloge, A. ^{[1
,11
,12
]}

Delorme, C. ^{[7
,11
]}

Denizot, H. ^{[11
]}

Dorey, J. M. ^{[6
,11
]}

Dubertret, C. ^{[6
,8
,11
]}

Dubreucq, J. ^{[7
,8
,11
]}

Faget, C. ^{[7
,9
,11
]}

Fluttaz, C. ^{[7
,11
]}

Fond, G. ^{[4
,11
]}

Fonteneau, S. ^{[10
,11
]}

Gabayet, F. ^{[7
,9
,11
]}

Giraud-Baro, E. ^{[7
,11
]}

Hardy-Bayle, M. C. ^{[10
,11
]}

机构：

[1] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France

[2] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translationnelle Strasbourg, Strasbourg, France

[3] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand 1, France

[4] Univ Paris Est Creteil, Pole Psychiat & daddictol, Hop Univ H Mondor,DHU Pe PSY, AP HP,INSERM U955,Eq 15 Psychiat Translationelle, Creteil, France

[5] Univ Montpellier I, Serv Univ Psychiat Adulte, Hop Colombiere, CHRU Montpellier,Inserm 1061, Montpellier, France

[6] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, CNRS UMR5292, INSERM U1028,Ctr Hosp La Vinatier,Pole Est,Equipe, 95 Bd Pinel,BP 30039, F-69678 Bron, France

[7] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France

[8] Univ Paris Diderot, Louis Mourier Hosp, AP HP, Dept Psychiat,Inserm U894,Sorbonne Paris Cite,Fac, Paris, France

[9] Pole Univ Psychiat, AP HM, Marseille, France

[10] Univ Versailles St Quentin En Yvelines, Ctr Hosp Versailles, Serv Univ Psychiat Adulte, Lab HandiRESP EA4047, Le Chesnay, France

[11] Fdn FondaMental, 40 Rue Mesly, F-94000 Creteil, France

[12] Univ Bordeaux, CNRS UMR INCIA 5287, Bordeaux, France

[13] Univ Bordeaux, INSERM, Neuroctr Magendie Physiopathol Plast Neuronale, U862, F-33000 Bordeaux, France

[14] INSERM U955, Translat Psychiat Team, Creteil, France

[15] Pole Psychiat Univ, CHU St Marguerite, F-13274 Marseille 9, France

[16] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France

[17] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translationnelle Strasbourg, Strasbourg, France

[18] INCIA, CNRS UMR 5287, Bordeaux, France

[19] Univ Paris 06, UPMC, Sorbonne Univ, INSERM,UMR S 1136,Inst Pierre Louis Epidemiol & S, F-75013 Paris, France

[20] Paris Est Univ, Hop Univ H Mondor, DHU Pe PSY, Pole Psychiat Hop, Creteil, France

来源：

SCHIZOPHRENIA RESEARCH | 2018年 / 195卷

关键词：

Schizophrenia; Duration of untreated psychosis; Antipsychotic; Age at onset; Cannabis; FIRST-EPISODE PSYCHOSIS; 1ST-EPISODE PSYCHOSIS; CANNABIS USE; ADULT-ONSET; SCHIZOPHRENIA; METAANALYSIS; ADOLESCENTS; DISORDERS; BIPOLAR; PATHOPHYSIOLOGY;

D O I：

10.1016/j.schres.2017.08.058

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objectives: Reducing the duration of untreated psychosis (DUP) may improve the prognosis of schizophrenia. This study investigated the prevalence, and associated risk factors, of long DUP in a large, non-selected sample of community-dwelling schizophrenia patients (SZ). Method: 478 community-dwelling stable SZ participants (122 women and 356 men; mean age 32.37 +/- 9.86 years) were recruited between 2010 and 2016. The mean retrospective DUP was evaluated from both patient and family reports, as well as hospital/psychiatrists records. Long DUP was defined as >2 years. Results: The mean DUP was 1.5 years. 80 participants (16.7%) had a DUP >2 years. In multivariate analyses, after adjustment for sex, education level, history of childhood trauma and history of maternal schizophrenia or bipolar disorder, long DUP was associated with a younger age of illness onset (19.3 +/- 6.67 years vs. 22.0 +/- 6.51 years, adjusted odd ratio aOR = 0.91, 95% CI [0.86; 0.97], p = 0.003) and cannabis use disorder (20.0% vs. 10.3%, aOR = 2.41, 95% CI [1.14-5.09], p = 0.02). Conclusion: A high proportion of SZ patients still have a long DUP. The present results suggest that illness onset before age 19 years and cannabis use are associated with long DUP in schizophrenia patients. Early psychosis detection programs should prioritize the targeting of these populations. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：529 / 533

页数：5

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