Circulating microRNAs in adrenal tumors

被引：7

作者：

Igaz, Peter ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Hungarian Acad Sci, Fac Med, Dept Internal Med 2, Budapest, Hungary

[2] Semmelweis Univ, Hungarian Acad Sci, MTA SE Mol Med Res Grp, Budapest, Hungary

来源：

CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY | 2019年 / 26卷 / 03期

关键词：

adenoma; adrenocortical; cancer; circulating; microRNA; myelolipoma; pheochromocytoma; PHEOCHROMOCYTOMA; PATHOGENESIS; MIRNA; MIR-483-5P; DIAGNOSIS; PROFILES; MARKERS;

D O I：

10.1097/MED.0000000000000472

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Circulating microRNAs represent promising minimally invasive markers of several diseases including tumors. As the preoperative diagnosis of different adrenal tumors is difficult, for example, diagnosis of adrenocortical or adrenomedullary malignancy, circulating microRNAs might be helpful in their clinical management. Recent findings Observations regarding the applicability of circulating microRNAs isolated both from unfractionated plasma or serum and from extracellular vesicle preparations for the diagnosis of adrenocortical malignancy have been published. Data show that circulating microRNA might be exploited for monitoring adrenocortical cancer progression. Circulating microRNA profiles of adrenal myelolipoma have also been published that might be useful for differentiating adrenocortical cancer and adrenal myelolipoma in dubious cases. Summary In this review, recent advances in the field of circulating microRNAs in adrenal tumors are discussed.

引用

页码：155 / 159

页数：5

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