Acanthocyclamine A From the Indonesian Marine Sponge Acanthostrongylophora ingens

被引：8

作者：

Dewi, Ariyanti S. ^{[1
,2
]}

Hadi, Tri A. ^{[3
]}

Fajarningsih, Nurrahmi D. ^{[2
]}

Blanchfield, Joanne T. ^{[1
]}

Bernhardt, Paul V. ^{[1
]}

Garson, Mary J. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia

[2] Minist Marine Affairs & Fisheries, Res & Dev Ctr Marine & Fisheries Prod Proc & Biot, Jakarta 10260, Indonesia

[3] Indonesian Inst Sci, Res Ctr Oceanog, Jakarta 14430, Indonesia

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2014年 / 67卷 / 8-9期

关键词：

ALKYLPIPERIDINE ALKALOIDS; CYTOTOXIC ALKALOIDS; HALICLONACYCLAMINES;

D O I：

10.1071/CH14107

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new 3-alkylpiperidine compound (-)-acanthocyclamine A (1) has been obtained from the methanolic extract of Acanthostrongylophora ingens (order Haplosclerida, family Petrosiidae) collected from Wakatobi Marine National Park in South East Sulawesi, Indonesia. The structure of 1 was investigated by extensive 1D- and 2D-NMR experiments. The absolute configuration of 1 was established by X-ray crystallography from anomalous dispersion effects using Cu radiation as C2 (R), C3 (R), C7 (R), and C9 (R). A plausible biosynthetic scheme leading to 1 is presented, and compared with the biosynthetic pathway proposed for the manzamine alkaloids.

引用

页码：1205 / 1210

页数：6

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