Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man

被引：214
作者：
Boube, M [1 ]
Joulia, L [1 ]
Cribbs, DL [1 ]
Bourbon, HM [1 ]
机构：
[1] Univ Toulouse 3, Ctr Dev Biol, F-31062 Toulouse, France
来源：
CELL | 2002年 / 110卷 / 02期
关键词：
D O I：
10.1016/S0092-8674(02)00830-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mediator complexes (MED) link transcriptional regulators to RNA polymerase II. Here, we summarize the latest advances on the functional organization of yeast Mediator. We argue for the existence of a "universal" Mediator structurally conserved from yeast to man, based on an extensive analysis of sequence databases. Finally, we examine the implications of these observations for the physiological roles of metazoan MED subunits.
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收藏
页码：143 / 151
页数：9
相关论文
共 58 条
[1]   Conserved structures of mediator and RNA polymerase II holoenzyme [J].
Asturias, FJ ;
Jiang, YW ;
Myers, LC ;
Gustafsson, CM ;
Kornberg, RD .
SCIENCE, 1999, 283 (5404) :985-987
[2]   CONTACT WITH A COMPONENT OF THE POLYMERASE-II HOLOENZYME SUFFICES FOR GENE ACTIVATION [J].
BARBERIS, A ;
PEARLBERG, J ;
SIMKOVICH, N ;
FARRELL, S ;
REINAGEL, P ;
BAMDAD, C ;
SIGAL, G ;
PTASHNE, M .
CELL, 1995, 81 (03) :359-368
[3]   The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II [J].
Bhoite, LT ;
Yu, YX ;
Stillman, DJ .
GENES & DEVELOPMENT, 2001, 15 (18) :2457-2469
[4]  
Björklund S, 2001, MOL CELLS, V11, P129
[5]   Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification [J].
Boube, M ;
Faucher, C ;
Joulia, L ;
Cribbs, DL ;
Bourbon, HM .
GENES & DEVELOPMENT, 2000, 14 (22) :2906-2917
[6]   Mammalian Srb Mediator complex is targeted by adenovirus E1A protein [J].
Boyer, TG ;
Martin, MED ;
Lees, E ;
Ricciardi, RP ;
Berk, AJ .
NATURE, 1999, 399 (6733) :276-279
[7]   Genetics of transcriptional regulation in yeast: Connections to the RNA polymerase II CTD [J].
Carlson, M .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 :1-23
[8]   A NEW FACTOR RELATED TO TATA-BINDING PROTEIN HAS HIGHLY RESTRICTED EXPRESSION PATTERNS IN DROSOPHILA [J].
CROWLEY, TE ;
HOEY, T ;
LIU, JK ;
JAN, YN ;
JAN, LY ;
TJIAN, R .
NATURE, 1993, 361 (6412) :557-561
[9]   Structural organization of yeast and mammalian mediator complexes [J].
Dotson, MR ;
Yuan, CX ;
Roeder, RG ;
Myers, LC ;
Gustafsson, CM ;
Jiang, YW ;
Li, Y ;
Kornberg, RD ;
Asturias, FJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (26) :14307-14310
[10]   A MEDIATOR REQUIRED FOR ACTIVATION OF RNA POLYMERASE-II TRANSCRIPTION INVITRO [J].
FLANAGAN, PM ;
KELLEHER, RJ ;
SAYRE, MH ;
TSCHOCHNER, H ;
KORNBERG, RD .
NATURE, 1991, 350 (6317) :436-438
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