StructAlign, a program for alignment of structures of DNA-protein complexes

被引：0
|
作者：
Popov, Ya. V. [1 ]
Galitsyna, A. A. [1 ]
Alexeevski, A. V. [1 ,2 ,3 ]
Karyagina, A. S. [2 ,4 ,5 ]
Spirin, S. A. [1 ,2 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Fac Bioengn & Bioinformat, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia
[3] Russian Acad Sci, Inst Syst Studies, Moscow 117218, Russia
[4] Gamaleya Ctr Epidemiol & Microbiol, Moscow 123098, Russia
[5] Inst Agr Biotechnol, Moscow 127550, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2015年 / 80卷 / 11期
基金：
俄罗斯基础研究基金会; 俄罗斯科学基金会;
关键词：
structural bioinformatics; DNA-protein complexes; alignment; web interface;
D O I：
10.1134/S0006297915110073
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Comparative analysis of structures of complexes of homologous proteins with DNA is important in the analysis of DNA-protein recognition. Alignment is a necessary stage of the analysis. An alignment is a matching of amino acid residues and nucleotides of one complex to residues and nucleotides of the other. Currently, there are no programs available for aligning structures of DNA-protein complexes. We present the program StructAlign, which should fill this gap. The program inputs a pair of complexes of DNA double helix with proteins and outputs an alignment of DNA chains corresponding to the best spatial fit of the protein chains.
引用
收藏
页码：1465 / 1468
页数：4
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