Copper-catalyzed radical oxidative C(sp3)-H/C(sp3)-H cross-coupling between arylacetonitriles and benzylic compounds

被引：2
作者：
Xiao, Jing [1 ]
Li, Fangshao [1 ]
Zhong, Ting [1 ]
Wu, Xiaofang [1 ]
Guo, Fengzhe [1 ]
Li, Qiang [2 ]
Tang, Zi-Long [1 ]
机构：
[1] Hunan Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Theoret Organ Chem & Funct Mol, Minist Educ, Xiangtan 411201, Peoples R China
[2] Liaocheng Univ, Sch Chem & Chem Engn, Inst Funct Organ Mol & Mat, 1 Hunan St, Liaocheng 252059, Shandong, Peoples R China
来源：
TETRAHEDRON | 2020年 / 76卷 / 48期
基金：
中国国家自然科学基金;
关键词：
Copper-catalyzed; Radical; C(sp(3))-H/C(sp(3))-H cross-coupling; Arylacetonitriles; Benzylic compounds; ALPHA-ALKYLATION; SECONDARY ALCOHOLS; NITRILES; FUNCTIONALIZATION; BONDS; MONOALKYLATION; HYDROTALCITE; ACETONITRILE; ACTIVATION; CYANATION;
D O I：
10.1016/j.tet.2020.131621
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
For the first time, a novel copper-catalyzed direct C(sp(3))-H/C(sp(3))-H cross-coupling of arylacetonitriles with unactivated benzylic compounds was described, allowing various a-benzylated arylacetonitriles to be readily accessible under base-free conditions. Mechanistic investigations suggested that the reaction proceeds through radical process and the C(sp(3))-H cleavage of arylacetonitriles probably is the rate-determining step. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：7
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