Sexual dysfunctions are associated with major depression, chronic inflammation and anticholinergic consumption in the real-world schizophrenia FACE-SZ national cohort

被引：11

作者：

Fond, G. ^{[1
,3
]}

Godin, O. ^{[1
,14
,17
]}

Dumontaud, M. ^{[1
,3
]}

Faget, C. ^{[1
,3
]}

Schurhoff, F. ^{[1
,2
,15
]}

Berna, F. ^{[1
,5
]}

Aouizerate, B. ^{[1
,4
,12
]}

Capdevielle, D. ^{[1
,6
]}

Chereau, I ^{[1
,7
]}

D'Amato, T. ^{[1
,8
]}

Dubertret, C. ^{[1
,9
,16
]}

Dubreucq, J. ^{[1
,10
]}

Leignier, S. ^{[1
,10
]}

Mallet, J. ^{[1
,9
,16
]}

Misdrahi, D. ^{[1
,4
,13
]}

Passerieux, C. ^{[1
,11
]}

Rey, R. ^{[1
,8
]}

Schandrin, A. ^{[1
,6
]}

Szoke, A. ^{[1
,2
,15
]}

Urbach, M. ^{[1
,11
]}

Vidailhet, P. ^{[5
]}

Leboyer, M. ^{[1
,2
,15
]}

Lancon, C. ^{[1
,3
]}

Boyer, L. ^{[1
,3
]}

Llorca, P. M. ^{[1
,7
]}

机构：

[1] Fdn FondaMental, Creteil, France

[2] INSERM U955, Equipe Psychiat Translat, Creteil, France

[3] Aix Marseille Univ, Fac Med, EA CEReSS Ctr Etud & Rech Serv Sante & Qualite Vi, Sect Timone, 27 Blvd Jean Moulin, F-13005 Marseille, France

[4] Univ Bordeaux, Ctr Hosp Charier Perrens, F-33076 Bordeaux, France

[5] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France

[6] Univ Montpellier I, Inserm 1061, CHRU Montpellier, Serv Univ Psychiat Adulte,Hop Colombiere, Montpellier, France

[7] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand 1, France

[8] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, CNRS UMR5292, Equipe PSYR2,Ctr Hosp Le Vinatier,INSERM U1028, 95 Bd Pinel,BP 30039, F-69678 Bron, France

[9] Louis Mourier Hosp, AP HP, Dept Psychiat, Colombes, France

[10] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France

[11] Univ Versailles St Quentin En Yvelines, UFR Sci Sante Simone Veil, Ctr Hosp Versailles, Serv Psychiat & Addictol Adulte,EA 4047 HANDIReSP, Versailles, France

[12] Univ Bordeaux, NutriNeuro, INRA, U1286, F-33076 Bordeaux, France

[13] CNRS UMR 5287 INCIA, F-33076 Bordeaux, France

[14] UPMC Univ Paris 06, Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, UMR S 1136, F-75013 Paris, France

[15] Univ Paris Est Creteil, Hop Univ H Mondor, Pole Psychiat, DHU Pe PSY, Creteil, France

[16] Univ Paris Diderot, Sorbonne Paris Cite, Inserm U894, Fac Med, Paris, France

[17] INSERM, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2019年 / 94卷

关键词：

Sexual dysfunctions; Schizophrenia; Antipsychotics; Major depression; Inflammation; QUALITY-OF-LIFE; SYMPTOMS; ANTIPSYCHOTICS; DISORDERS; VALIDITY; HORMONES; SCALE;

D O I：

10.1016/j.pnpbp.2019.109654

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Sexual dysfunctions (SD) are frequent in schizophrenia (SZ) and associated with treatment withdrawal, however they remain under-explored and under-treated. To date, most of the studies have focused on SD as antipsychotics' side effects in therapeutic trials. Aims: The objectives of the present study were to determine the SD prevalence in stabilized SZ outpatients and their clinical, pharmacological and biological correlates. Method: Two hundred and thirty-seven participants (61.2% men) were consecutively included and received a thorough 2 days-clinical assessment including the self-reported Sexual Functioning Questionnaire (SFQ). SD was defined by a SFQ score >= 8. Results: Two hundred and thirty-seven subjects were recruited in the FACE-SZ cohort, 41% of them reported sexual dysfunctions. In multivariate analyses, SD have been associated with current major depressive disorder (adjusted odd ratio aOR= 2.29[1.08-4.85], p = .03), anticholinergic prescription (aOR = 2.65, p = .02) and chronic low-grade inflammation (aOR = 2.09, p = .03) independently of age, gender, current cannabis use disorder and olanzapine prescription. No antipsychotic has been associated with increased or decreased SD rate. Conclusions: SD are frequent in SZ subjects. Major depression, anticholinergic prescription and chronic low-grade peripheral inflammation may be the three targets of interest for addressing this specific issue.

引用

页数：8

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