Immunopathology alters Th17 cell glucocorticoid sensitivity

被引：51

作者：

Banuelos, J. ^{[1
]}

Cao, Y. ^{[1
]}

Shin, S. C. ^{[1
]}

Lu, N. Z. ^{[1
]}

机构：

[1] Northwestern Univ, Div Allergy Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

ALLERGY | 2017年 / 72卷 / 03期

关键词：

asthma; autoimmunity; glucocorticoid resistance; glucocorticoids; Th17; cells; ROR-GAMMA-T; INNATE LYMPHOID-CELLS; ALLERGIC AIRWAY INFLAMMATION; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; DOUBLE-BLIND; TGF-BETA; SEVERE ASTHMA; T(H)17 CELLS; MONOCLONAL-ANTIBODY;

D O I：

10.1111/all.13051

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

引用

页码：331 / 341

页数：11

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