Syntheses and Insecticidal Activities of Nitro Arylideneamino Guanidine Derivatives

In order to search for better lead compounds with excellent biological activities, a novel series of acyclic neonicotinoids of nitro arylideneamino guanidine derivatives was designed and synthesized from nitroaminoguanidine by the method of linking the active substructures of neonicotiniod insecticides and semicarbazone insecticides. All the target compounds were confirmed by H-1 NMR, IR and elemental analysis. The preliminary bioassay showed that the lethal rates of target compounds to Myzuspersicae were excellent at the concentration of 600 mu g/mL. The lethal rates of several compounds, such as 4-2, 4-8, 4-10, 4-16, 4-27, 4-31 and 4-34, were more than 90%. Further research of compounds 4-2, 4-8 and 4-34 against Myzuspersicae, Aphis gossypii and Hyalopterusamygdali blanchard indicated these compounds possessed high activity at low concentrations, especially, the activity of compound 4-8 was better than that of imidacloprid against Hyalopteraamygdali blanchard, its lethal rate was 95.7% compared to imidacloprid(79.4%) at the concentration of 3.13 mu g/mL, which confirmed that this compound is worth of research.