Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

被引：30

作者：

Bateman, D. Nicholas ^{[1
]}

Dear, James W. ^{[1
]}

机构：

[1] Univ Edinburgh, Pharmacol Toxicol & Therapeut, Edinburgh, Midlothian, Scotland

来源：

TOXICOLOGY RESEARCH | 2019年 / 8卷 / 04期

关键词：

INTRAVENOUS N-ACETYLCYSTEINE; INDUCED HEPATIC-NECROSIS; ACETAMINOPHEN OVERDOSE; ADVERSE REACTIONS; ANAPHYLACTOID REACTIONS; GLUTATHIONE DEPLETION; COVALENT BINDING; RISK-FACTORS; TOXICITY; INJURY;

D O I：

10.1039/c9tx00002j

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future.

引用

页码：489 / 498

页数：10

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