Two novel lignans from Gaultheria yunnanensis

被引：9

作者：

Gao, Yan-Ping ^{[1
,2
]}

Shen, Yun-Heng ^{[1
]}

Xu, Xi-Ke ^{[1
]}

Tian, Jun-Mian ^{[1
]}

Zeng, Hua-Wu ^{[1
]}

Lin, Sheng ^{[1
]}

Liu, Chun-Mei ^{[1
]}

Zhang, Wei-Dong ^{[1
,2
,3
,4
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Jiangxi Univ Tradit Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethen Med, Nanchang 330004, Peoples R China

[3] King Saud Univ, Riyadh 11451, Saudi Arabia

[4] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2014年 / 16卷 / 07期

关键词：

Gaultheria yunnanensis; Ericaceae; lignans; anti-inflammatory activity;

D O I：

10.1080/10286020.2014.898634

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis. Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9 positions of aryl-tetralin lignan skeleton. All nine compounds were assayed for inhibitory effects against nitric oxide and pro-inflammatory cytokines TNF- and IL-6 release in LPS-induced RAW 246.7 macrophages, while no significant activities were observed for the evaluated compounds.

引用

页码：724 / 729

页数：6

共 11 条

[1] STUDIES ON ALLAMANDA .3. 9-ALPHA-HYDROXYPINORESINOL, 9-ALPHA-HYDROXYMEDIORESINOL AND RELATED LIGNANS FROM ALLAMANDA NERIIFOLIA [J].

ABE, F ;

YAMAUCHI, T .

PHYTOCHEMISTRY, 1988, 27 (02) :575-577

[2]

Fang RC, 1999, NOVON, V9, P162

[3]

FONSECA S F, 1978, Phytochemistry (Oxford), V17, P499, DOI 10.1016/S0031-9422(00)89347-4

[4] Bioactive constituents from roots of Bursera tonkinensis [J].

Jutiviboonsuk, A ;

Zhang, HJ ;

Tan, GT ;

Ma, CY ;

Van Hung, N ;

Cuong, NM ;

Bunyapraphatsara, N ;

Soejarto, DD ;

Fong, HHS .

PHYTOCHEMISTRY, 2005, 66 (23) :2745-2751

[5] NEOLIGNANS AND A PHENYLPROPANOID GLUCOSIDE FROM ILLICIUM-DIFENGPI [J].

KOUNO, I ;

YANAGIDA, Y ;

SHIMONO, S ;

SHINTOMI, M ;

ITO, Y ;

YANG, CS .

PHYTOCHEMISTRY, 1993, 32 (06) :1573-1577

[6]

Kylne W., 1966, J CHEM SOC C, V9, P893

[7]

Ma X.J., 2001, CHIN TRADIT HERBAL D, V32, P945, DOI [10.7501/j.issn.0253-2670.2001.10.2001010511, DOI 10.7501/J.ISSN.0253-2670.2001.10.2001010511]

[8]

Utsunomiya H., 2011, Japan patent JP, Patent No. 2011246419

[9] Gaultherin, a natural salicylate derivative from Gaultheria yunnanensis:: Towards a better non-steroidal anti-inflammatory drug [J].

Zhang, B ;

He, XL ;

Ding, Y ;

Du, GH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2006, 530 (1-2) :166-171

[10] Gaultherins A and B, two lignans from Gaultheria yunnanensis [J].

Zhang, ZZ ;

Guo, D ;

Li, CL ;

Zheng, JH ;

Koike, K ;

Jia, ZH ;

Nikaido, T .

PHYTOCHEMISTRY, 1999, 51 (03) :469-472

← 1 2 →