Hepatoprotective activity of Clerodendrum inerme against CCL4 induced hepatic injury in rats

The ethanolic extract of Clerodendrum inerme leaves were screened for its hepatoprotective activity in CCl4 (0.5 ml/kg, i.p) induced liver damage in Swiss albino rats at a dose of 200 mg/kg bw. The ethanolic extract of C inerme significantly (P < 0.001) decreases the serum enzyme alanine amino transferase (ALT), asparate amino transferase (AST), alkaline phosphates (ALP), triglycerides (TGL), total cholesterol (TC) and significantly increased the glutathione level. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P < 0.001). The extract did not shown any mortality up to a dose of 2000 g/kg bw. (c) 2007 Elsevier B.V. All rights reserved.