Molecular Epidemiology of Escherichia coli Sequence Type 131 and Its H30 and H30-Rx Subclones among Extended-Spectrum-β-Lactamase-Positive and -Negative E. coli Clinical Isolates from the Chicago Region, 2007 to 2010

被引：102

作者：

Banerjee, Ritu ^{[1
]}

Robicsek, Ari ^{[2
]}

Kuskowski, Michael A. ^{[3
,4
]}

Porter, Stephen ^{[3
,4
]}

Johnston, Brian D. ^{[3
,4
]}

Sokurenko, Evgeni ^{[5
]}

Tchesnokova, Veronika ^{[5
]}

Price, Lance B. ^{[6
,7
]}

Johnson, James R. ^{[3
,4
]}

机构：

[1] Mayo Clin, Rochester, MN USA

[2] NorthShore Univ HealthSyst, Evanston, IL USA

[3] Vet Affairs Med Ctr, Minneapolis, MN USA

[4] Univ Minnesota, Minneapolis, MN USA

[5] Univ Washington, Seattle, WA 98195 USA

[6] Translat Genom Res Inst, Flagstaff, AZ USA

[7] George Washington Univ, Washington, DC USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 12期

关键词：

INFECTIONS; ST131;

D O I：

10.1128/AAC.01604-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed Escherichia coli ST131 and its H30 and H30-Rx subclones for virulence genes, antimicrobial resistance, and extended-spectrum beta-lactamase (ESBL) type. Although both subclones were associated with ESBL production, H30-Rx isolates had higher resistance scores and were associated specifically with CTX-M-15. Three virulence genes (iha, sat, and iutA) were more prevalent among H30 than non-H30 ST131 isolates. Thus, the H30 and H30-Rx subclones are more antimicrobial resistant and have virulence profiles that are distinct from those of non-H30 ST131 isolates.

引用

收藏

页码：6385 / 6388

页数：4

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