Genetic variation in the glucocorticoid pathway involved in interindividual differences in the glucocorticoid treatment

被引：32
作者：
Song, Qian-Qian [1 ,2 ]
Xie, Wan-Ying [1 ,2 ]
Tang, Yong-Jun [1 ,2 ]
Zhang, Jun [3 ]
Liu, Jie [1 ,2 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China
来源：
PHARMACOGENOMICS | 2017年 / 18卷 / 03期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
glucocorticoid; glucocorticoid pathway; glucocorticoid resistance; pharmacogenetics; polymorphisms; ACUTE LYMPHOBLASTIC-LEUKEMIA; INFLAMMATORY-BOWEL-DISEASE; IMPROVED LUNG-FUNCTION; LIGAND-BINDING DOMAIN; PERIPHERAL-BLOOD LYMPHOCYTES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; P-GLYCOPROTEIN EXPRESSION; RECEPTOR GENE; NEPHROTIC SYNDROME; POINT MUTATION;
D O I：
10.2217/pgs-2016-0151
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Glucocorticoids (GCs) are widely used for treating asthma, rheumatoid arthritis, nephrotic syndrome, acute lymphoblastic leukemia and other autoimmune diseases. However, in a subgroup of patients, failure to respond to GCs is known as GC resistance or GC insensitivity. This represents an important barrier to effective treatment and a clinical problem requiring an urgent solution. Genetic variation in the GC pathway is a significant factor in interindividual differences in GC treatment. This article reviews the pharmacogenetics of GCs in diverse diseases based on the GC pathway.
引用
收藏
页码：293 / 316
页数：24
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