Genetic variation in the glucocorticoid pathway involved in interindividual differences in the glucocorticoid treatment

被引：32

作者：

Song, Qian-Qian ^{[1
,2
]}

Xie, Wan-Ying ^{[1
,2
]}

Tang, Yong-Jun ^{[1
,2
]}

Zhang, Jun ^{[3
]}

Liu, Jie ^{[1
,2
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp, Dept Nephrol, Changsha 410008, Hunan, Peoples R China

来源：

PHARMACOGENOMICS | 2017年 / 18卷 / 03期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

glucocorticoid; glucocorticoid pathway; glucocorticoid resistance; pharmacogenetics; polymorphisms; ACUTE LYMPHOBLASTIC-LEUKEMIA; INFLAMMATORY-BOWEL-DISEASE; IMPROVED LUNG-FUNCTION; LIGAND-BINDING DOMAIN; PERIPHERAL-BLOOD LYMPHOCYTES; SYSTEMIC-LUPUS-ERYTHEMATOSUS; P-GLYCOPROTEIN EXPRESSION; RECEPTOR GENE; NEPHROTIC SYNDROME; POINT MUTATION;

D O I：

10.2217/pgs-2016-0151

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucocorticoids (GCs) are widely used for treating asthma, rheumatoid arthritis, nephrotic syndrome, acute lymphoblastic leukemia and other autoimmune diseases. However, in a subgroup of patients, failure to respond to GCs is known as GC resistance or GC insensitivity. This represents an important barrier to effective treatment and a clinical problem requiring an urgent solution. Genetic variation in the GC pathway is a significant factor in interindividual differences in GC treatment. This article reviews the pharmacogenetics of GCs in diverse diseases based on the GC pathway.

引用

页码：293 / 316

页数：24

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