Synthesis and Biological Activity of 4-Chloro-1H-Imidazole-5-Carbaldehyde Thiosemicarbazones

被引：5

作者：

Chornous, V. A. ^{[1
]}

Grozav, A. N. ^{[1
]}

Todoriko, L. D. ^{[1
]}

Vovk, M. V. ^{[2
]}

机构：

[1] Bukovinian State Med Univ, UA-58000 Chernovtsy, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev, Ukraine

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 47卷 / 10期

关键词：

4-chloro-5-formylimidazoles; thiosemicarbazones; antituberculosis and antimicrobial activity;

D O I：

10.1007/s11094-014-0996-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of thiosemicarbazones, the structures of which were established by IR and PMR spectroscopy and mass spectrometry, were synthesized by condensation of 4-chloro-1H-imidazole-5-carbaldehydes with thiosemicarbazide. Some of the synthesized compounds were found to exhibit high inhibitory activity with respect to M. tuberculosis strains that was 1.5 times more effective than the reference drug isoniazid. Astudy of the antimicrobial activity of the synthesized thiosemicarbazones showed that their fungistatic properties were more pronounced than their bacteriostatic properties.

引用

页码：524 / 526

页数：3

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