Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: A randomized, observer-blind, vehicle-controlled trial

被引：62

作者：

Lin, Yin-Ku ^{[1
,2
]}

See, Lai-Chu ^{[3
,4
]}

Huang, Yu-Huei ^{[5
,6
]}

Chang, Ya-Ching ^{[5
,6
]}

Tsou, Teng-Cheng ^{[1
]}

Lin, Tung-Yi ^{[1
]}

Lin, Na-Ling ^{[3
,4
]}

机构：

[1] Chang Gung Mem Hosp Keelung, Dept Tradit Chinese Med, Keelung, Taiwan

[2] Chang Gung Univ, Sch Tradit Chinese Med, Taoyuan, Taiwan

[3] Chang Gung Univ, Biostat Consultat Ctr, Dept Publ Hlth, Taoyuan, Taiwan

[4] Chang Gung Univ, Mol Med Res Ctr, Biostat Core Lab, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp Taipei, Dept Dermatol, Taipei, Taiwan

[6] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

来源：

PHYTOMEDICINE | 2014年 / 21卷 / 07期

关键词：

Traditional Chinese medicine; Indigo naturalis; Indirubin; Psoriasis; Nail psoriasis; HUMAN KERATINOCYTES; SEVERITY INDEX; OLIVE OIL; OINTMENT; EXPRESSION; INDIRUBIN;

D O I：

10.1016/j.phymed.2014.02.013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Treating nail psoriasis is notoriously difficult and lacks standardized therapeutic regimens. Indigo naturalis has been demonstrated to be safe and effective in treating skin psoriasis. This trial was conducted to evaluate the efficacy and safety of refined indigo naturalis extract in oil (Lindioil) in treating nail psoriasis. Thirty-one outpatients with symmetrically comparable psoriatic nails were enrolled. Lindioil (experimental group) or olive oil (control group) was applied topically to the same subjects' two bilaterally symmetrical psoriatic nails twice daily for the first 12 weeks and then subjects applied Lindioil to both hands for 12 additional weeks. Outcomes were measured using Nail Psoriasis Severity Index (NAPS!) for five nails on one hand and for the single most severely affected nail from either hand. The results show a reduction of NAPSI scores for the 12-week treatment for the Lindioil group (49.8% for one hand and 59.3% for single nail) was superior to the reduction in the scores for the control group (22.9%, 16.3%, respectively). There were no adverse events during the 24 weeks of treatment. This trial demonstrates that Lindioil is a novel, safe and effective therapy for treating nail psoriasis. (C) 2014 Elsevier GmbH. All rights reserved.

引用

页码：1015 / 1020

页数：6

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