A European Respiratory Society technical standard: exhaled biomarkers in lung disease

被引：499

作者：

Horvath, Ildiko ^{[1
]}

Barnes, Peter J. ^{[2
]}

Loukides, Stelios ^{[3
]}

Sterk, Peter J. ^{[4
]}

Hogman, Marieann ^{[5
]}

Olin, Anna-Carin ^{[6
]}

Amann, Anton ^{[7
]}

Antus, Balazs ^{[8
]}

Baraldi, Eugenio ^{[9
]}

Bikov, Andras ^{[10
]}

Boots, Agnes W. ^{[11
]}

Bos, Lieuwe D. ^{[12
]}

Brinkman, Paul ^{[4
]}

Bucca, Caterina ^{[13
]}

Carpagnano, Giovanna E. ^{[14
]}

Corradi, Massimo ^{[15
]}

Cristescu, Simona ^{[16
]}

de Jongste, Johan C. ^{[17
]}

Dinh-Xuan, Anh-Tuan ^{[18
]}

Dompeling, Edward ^{[19
]}

Fens, Niki ^{[4
]}

Fowler, Stephen ^{[20
]}

Hohlfeld, Jens M. ^{[21
,22
]}

Holz, Olaf ^{[21
]}

Jobsis, Quirijn ^{[23
]}

Van De Kant, Kim ^{[19
]}

Knobel, Hugo H. ^{[24
]}

Kostikas, Konstantinos ^{[25
]}

Lehtimaki, Lauri ^{[26
]}

Lundberg, Jon ^{[27
]}

Montuschi, Paolo ^{[28
]}

Van Muylem, Alain ^{[29
]}

Pennazza, Giorgio ^{[30
]}

Reinhold, Petra ^{[31
]}

Ricciardolo, Fabio L. M. ^{[32
]}

Rosias, Philippe ^{[19
,33
]}

Santonico, Marco ^{[30
]}

van der Schee, Marc P. ^{[4
]}

van Schooten, Frederik-Jan ^{[11
]}

Spanevello, Antonio ^{[34
]}

Tonia, Thomy ^{[35
]}

Vink, Teunis J. ^{[24
]}

机构：

[1] Natl Koranyi Inst Pulmonol, Dept Pulmonol, Piheno Ut 1, Budapest, Hungary

[2] Imperial Coll London, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England

[3] Nimits Hosp, Pulm Dept, Athens, Greece

[4] Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands

[5] Uppsala Univ, Ctr Res & Dev, Cty Council Gavle, Gavle, Sweden

[6] Sahlgrenska Acad & Univ Hosp, Occupat & Environm Med, Gothenburg, Sweden

[7] Innsbruck Med Univ, Innsbruck, Austria

[8] Natl Koranyi Inst Pulmonol, Dept Pathophysiol, Budapest, Hungary

[9] Univ Padua, Pediat Pneumonol, Padua, Italy

[10] Semmelweis Univ, Dept Pulmonol, Budapest, Hungary

[11] Maastricht Univ, Dept Pharmacol & Toxicol, Maastricht, Netherlands

[12] Univ Amsterdam, Acad Med Ctr, Intens Care, Amsterdam, Netherlands

[13] Univ Torino, Biomed Sci & Human Oncol, Turin, Italy

[14] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy

[15] Univ Parma, Parma, Italy

[16] Radboud Univ Nijmegen, Inst Mol & Mat, Dept Mol & Laser Phys, Nijmegen, Netherlands

[17] Erasmus MC Sophia Childrens Hosp, Dept Pediat Resp Med, Rotterdam, Netherlands

[18] Paris Descartes Univ, Cochin Hosp, Physiol, Paris, France

[19] Maastricht Univ, Med Ctr, Family Med Res Sch CAPHRI, Dept Paediat, Maastricht, Netherlands

[20] Univ Manchester Wythenshawe Hosp, Resp Res Grp, Manchester, Lancs, England

[21] Fraunhofer Inst Toxicol & Expt Med ITEM, Clin Airway Res, Hannover, Germany

[22] Medizin Hsch Hannover, Hannover, Germany

[23] Maastricht Univ, Med Ctr, Dept Paediat Resp Med, Maastricht, Netherlands

[24] Philips Res, High Tech Campus 11, Eindhoven, Netherlands

[25] Univ Athens, Med Sch, Resp Med Dept 2, Athens, Greece

[26] Univ Tampere, Med Sch, Tampere, Finland

[27] Karolinska Inst, Physiol & Pharmacol, Stockholm, Sweden

[28] Univ Cattolica Sacro Cuore, Pharmacol, Rome, Italy

[29] Hop Erasme Clin Univ Bruxelles, Brussels, Belgium

[30] Univ Campus Bio Med, Fac Engn, Rome, Italy

[31] Friedrich Loeffler Inst, Inst Mol Pathogenesis, Jena, Germany

[32] Univ Torino, Dept Clin & Biol Sci, Clin Resp Dis, Turin, Italy

[33] Maasland Hosp, Dept Pediat, Sittard, Netherlands

[34] Fdn Salvatore Maugeri, Tradate, Italy

[35] European Resp Soc, Lausanne, Switzerland

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 49卷 / 04期

关键词：

VOLATILE ORGANIC-COMPOUNDS; BREATH CONDENSATE PH; NASAL NITRIC-OXIDE; OBSTRUCTIVE PULMONARY-DISEASE; EXTENDED NO ANALYSIS; MASS-SPECTROMETRIC ANALYSIS; PRIMARY CILIARY DYSKINESIA; ELECTRONIC NOSE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS;

D O I：

10.1183/13993003.00965-2016

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management. Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members. Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised. Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

引用

页数：26

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