No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing

被引：165

作者：

Schmidtko, Achim ^{[1
]}

Tegeder, Irmgard ^{[1
]}

Geisslinger, Gerd ^{[1
]}

机构：

[1] Klinikum Goethe Univ, Inst Klin Pharmakol, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany

来源：

TRENDS IN NEUROSCIENCES | 2009年 / 32卷 / 06期

关键词：

DEPENDENT PROTEIN-KINASE; DORSAL-ROOT GANGLIA; SENSITIVE GUANYLYL CYCLASE; PERIPHERAL-NERVE INJURY; NEUROPATHIC PAIN; INFLAMMATORY PAIN; SENSORY NEURONS; THERMAL HYPERALGESIA; UP-REGULATION; PHARMACOLOGICAL INHIBITION;

D O I：

10.1016/j.tins.2009.01.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A large body of evidence indicates that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) essentially contribute to the processing of nociceptive signals in the spinal cord. Many animal studies have unanimously shown that inhibition of NO or cGMP synthesis can considerably reduce both inflammatory and neuropathic pain. However, experiments with NO donors and cGMP analogs also caused conflicting results because dual pronociceptive and antinociceptive effects of these molecules have been observed. Here, we summarize the most recent advances in the understanding of NO- and cGMP-dependent signaling pathways in the spinal cord and further unravel the role of NO and cGMP in pain processing.

引用

页码：339 / 346

页数：8

共 96 条

[1] LOCALIZATION OF NADPH-DIAPHORASE-CONTAINING NEURONS IN SENSORY GANGLIA OF THE RAT [J].