Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives

被引：61

作者：

Atia, Abdul Jabar Kh.

机构：

[1] Department of Chemistry, College of Sciences, The University of Mustansiriayah

来源：

MOLECULES | 2009年 / 14卷 / 07期

关键词：

metronidazole; biimidazole; imidazole; 1,3,4-oxadiazole; 1,2,4-triazole; 1,3,4-thiadiazole; 1,2,4-TRIAZOLES;

D O I：

10.3390/molecules14072431

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds 7a-c were synthesized by the reaction of compounds 6a-c with hydrazine hydrate. Biimidazole esters 9a-c were converted into biimidazole hydrazide esters 10a-c. Compounds 7a-c and 10a-c were converted into a variety of derivatives.

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页码：2431 / 2446

页数：16

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