Overcoming the penetration depth limit in optical microscopy: Adaptive optics and wavefront shaping

被引：28

作者：

Ahn, Cheolwoo ^{[1
]}

Hwang, Byungjae ^{[1
]}

Nam, Kibum ^{[1
]}

Jin, Hyungwon ^{[1
]}

Woo, Taeseong ^{[1
]}

Park, Jung-Hoon ^{[1
]}

机构：

[1] UNIST, Dept Biomed Engn, Ulsan, South Korea

来源：

JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES | 2019年 / 12卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

Adaptive optics; wavefront shaping; optical aberration; multiple scattering; in-vivo imaging; SINGLE-MOLECULE LOCALIZATION; ABERRATION CORRECTION; FOCUSING LIGHT; FLUORESCENCE MICROSCOPY; 2ND-HARMONIC RADIATION; DEPENDENT ABERRATIONS; STIMULATED-EMISSION; PHASE-CONJUGATION; SCATTERING MEDIA; RESOLUTION LIMIT;

D O I：

10.1142/S1793545819300027

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time, current applications are mostly limited to research settings. This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems. However, recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells, but can be significantly enhanced to realize deep tissue imaging. To provide insight into how these two closely related fields can expand the limits of bio imaging, we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissue imaging.

引用

页数：18

共 111 条

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