Chemopreventive potential of cyclic diarylheptanoids

被引:58
作者
Ishida, J
Kozuka, M
Tokuda, H
Nishino, H
Nagumo, S
Lee, KH [1 ]
Nagai, M
机构
[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA
[2] Hoshi Univ, Shinagawa Ku, Tokyo 1428501, Japan
[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan
关键词
D O I
10.1016/S0968-0896(02)00164-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Eleven cyclic diarylheptanoids and seven related compounds were screened as potential antitumor promoters by using the in vitro short-term 12-O-tetradecanoylphorbo-13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation assay. In addition, the cyclic diarylheptanoid myricanone (2) was examined for antitumor initiating activity in a two-stage carcinogenesis assay of mouse skin tumors induced by peroxynitrite as an initiator and TPA as a promoter. Myricanone (2) exhibited significant antitumor-initiating effect on mouse skin. These data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3361 / 3365
页数:5
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