Translational Control during Developmental Transitions

被引：57

作者：

Teixeira, Felipe Karam ^{[1
]}

Lehmann, Ruth ^{[2
,3
]}

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

[2] NYU, Sch Med, HHMI, New York, NY 10016 USA

[3] NYU, Sch Med, Kimmel Ctr Biol & Med, Skirball Inst,Dept Cell Biol, New York, NY 10016 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2019年 / 11卷 / 06期

基金：

美国国家卫生研究院;

关键词：

OSKAR MESSENGER-RNA; HEMATOPOIETIC STEM-CELLS; TO-ZYGOTIC TRANSITION; GENOME-WIDE ANALYSIS; HNRNP F/H HOMOLOG; BINDING-PROTEIN; CYTOPLASMIC POLYADENYLATION; DROSOPHILA HNRNP; SELF-RENEWAL; IN-VIVO;

D O I：

10.1101/cshperspect.a032987

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The many steps of gene expression, from the transcription of a gene to the production of its protein product, are well understood. Yet, transcriptional regulation has been the focal point for the study of gene expression during development. However, quantitative studies reveal that messenger RNA (mRNA) levels are not necessarily good predictors of the respective proteins' levels in a cell. This discrepancy is, at least in part, the result of developmentally regulated, translational mechanisms that control the spatiotemporal regulation of gene expression. In this review, we focus on translational regulatory mechanisms mediating global transitions in gene expression: the shift from the maternal to the embryonic developmental program in the early embryo and the switch from the self-renewal of stem cells to differentiation in the adult.

引用

页数：15

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