Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

被引：17
作者：
Huang, Lin-Chiang Sherlock [1 ,2 ,3 ]
Le, Dao [1 ,2 ,4 ,5 ]
Hsiao, I-Lun [6 ,7 ]
Fritsch-Decker, Susanne [6 ]
Hald, Christian [1 ,2 ]
Huang, Su-Ching [8 ]
Chen, Jen-Kun [8 ]
Hwu, Jih Ru [3 ]
Weiss, Carsten [6 ]
Hsu, Min-Hua [9 ]
Delaittre, Guillaume [1 ,2 ,10 ]
机构：
[1] Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany
[2] Karlsruhe Inst Technol KIT, Inst Chem Technol & Polymer Chem ITCP, Engesserstr 15, D-76131 Karlsruhe, Germany
[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan
[4] Sorbonne Univ, Inst Parisien Chim Mol IPCM, Polymer Chem Team ECP, F-75005 Paris, France
[5] CNRS, UMR 8232, 4 Pl Jussieu, F-75005 Paris, France
[6] Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst Biol Informat Proc IBCS BIP, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany
[7] Taipei Med Univ, Coll Nutr, Sch Food Safety, 250 Wuxing St, Taipei 11031, Taiwan
[8] Natl Hlth Res Inst, Inst Biomed Engn & Nanomed, 35 Keyan Rd, Zhunan Township 35053, Miaoli County, Taiwan
[9] Natl Changhua Univ Educ, Dept Chem, Changhua 50007, Taiwan
[10] Univ Wuppertal, Organ Funct Mol, Organ Chem, Gaussstr 20, D-42119 Wuppertal, Germany
来源：
POLYMER CHEMISTRY | 2021年 / 12卷 / 01期
关键词：
CONTAINING POLYMERS; RAFT; ACID; CHEMISTRY; BOROXINE; DESIGN;
D O I：
10.1039/d0py00710b
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.
引用
收藏
页码：50 / 56
页数：7
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