Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

被引：17

作者：

Huang, Lin-Chiang Sherlock ^{[1
,2
,3
]}

Le, Dao ^{[1
,2
,4
,5
]}

Hsiao, I-Lun ^{[6
,7
]}

Fritsch-Decker, Susanne ^{[6
]}

Hald, Christian ^{[1
,2
]}

Huang, Su-Ching ^{[8
]}

Chen, Jen-Kun ^{[8
]}

Hwu, Jih Ru ^{[3
]}

Weiss, Carsten ^{[6
]}

Hsu, Min-Hua ^{[9
]}

Delaittre, Guillaume ^{[1
,2
,10
]}

机构：

[1] Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst Funct Mol Syst IBCS FMS, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[2] Karlsruhe Inst Technol KIT, Inst Chem Technol & Polymer Chem ITCP, Engesserstr 15, D-76131 Karlsruhe, Germany

[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan

[4] Sorbonne Univ, Inst Parisien Chim Mol IPCM, Polymer Chem Team ECP, F-75005 Paris, France

[5] CNRS, UMR 8232, 4 Pl Jussieu, F-75005 Paris, France

[6] Karlsruhe Inst Technol KIT, Inst Biol & Chem Syst Biol Informat Proc IBCS BIP, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany

[7] Taipei Med Univ, Coll Nutr, Sch Food Safety, 250 Wuxing St, Taipei 11031, Taiwan

[8] Natl Hlth Res Inst, Inst Biomed Engn & Nanomed, 35 Keyan Rd, Zhunan Township 35053, Miaoli County, Taiwan

[9] Natl Changhua Univ Educ, Dept Chem, Changhua 50007, Taiwan

[10] Univ Wuppertal, Organ Funct Mol, Organ Chem, Gaussstr 20, D-42119 Wuppertal, Germany

来源：

POLYMER CHEMISTRY | 2021年 / 12卷 / 01期

关键词：

CONTAINING POLYMERS; RAFT; ACID; CHEMISTRY; BOROXINE; DESIGN;

D O I：

10.1039/d0py00710b

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

引用

页码：50 / 56

页数：7

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