EFFECT OF PKP ON SERUM SOST IN PATIENTS WITH VERTEBRAL COMPRESSION FRACTURES

被引：3

作者：

Wang, Enzhi ^{[1
]}

Lin, Jianjun ^{[2
]}

Xu, Guangwei ^{[3
]}

Wang, Xinhua ^{[1
]}

Chen, Mifang ^{[4
]}

机构：

[1] Taizhou Integrated Chinese & Western Med Hosp, Dept Clin Lab, Taizhou, Zhejiang, Peoples R China

[2] Ningbo Fourth Hosp, Dept Clin Lab, Ningbo, Zhejiang, Peoples R China

[3] Ningbo Women & Childrens Hosp, Dept Orthoped, Ningbo, Zhejiang, Peoples R China

[4] Ningbo Women & Childrens Hosp, Dept Clin Lab, Ningbo, Zhejiang, Peoples R China

来源：

ACTA ORTOPEDICA BRASILEIRA | 2020年 / 28卷 / 06期

关键词：

Bone Density; Kyphoplasty; Osteoporosis; PERCUTANEOUS VERTEBROPLASTY; SCLEROSTIN; BONE; KYPHOPLASTY;

D O I：

10.1590/1413-785220202806228603

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Objective: This study sought to determine serum sclerostin (SOST) expression in patients with osteoporotic thoracolumbar vertebral compression fractures before and after percutaneous kyphoplasty (PKP). Methods: Serum SOST levels were quantified with a sandwich enzyme-linked immunosorbent assay (ELISA) preoperatively and six months postoperatively. Anterior vertebral height, kyphotic angles, and Visual Analogue Scale (VAS) scores were also recorded. Results: Serum SOST was highly expressed in patients and remained negatively correlated with bone mineral density (BMD). Vertebral heights, local kyphotic angles, and VAS scores were all significantly improved after PKP. However, serum SOST was positively correlated with BMD six months after surgery. Conclusion: PKP was an effective treatment strategy for osteoporotic thoracolumbar vertebral compression fractures, improving BMD and decreasing serum SOST levels.

引用

页码：323 / 326

页数：4

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