Recent progress concerning CpG DNA and its use as a vaccine adjuvant

被引：155

作者：

Shirota, Hidekazu ^{[1
]}

Klinman, Dennis M. ^{[2
]}

机构：

[1] Tohoku Univ, Dept Clin Oncol, Sendai, Miyagi 980, Japan

[2] NCI, Canc & Inflammat Program, Frederick, MD 21702 USA

来源：

EXPERT REVIEW OF VACCINES | 2014年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

allergy; cancer; CpG oligonucleotide; infection; Toll-like receptor; vaccine adjuvant; PLASMACYTOID DENDRITIC CELLS; B SURFACE-ANTIGEN; TOLL-LIKE RECEPTORS; DOUBLE-STRANDED-RNA; MUCOSAL IMMUNE-RESPONSES; NON-HODGKIN-LYMPHOMA; IN-SITU VACCINATION; BLOOD-STAGE VACCINE; RANDOMIZED PHASE-II; BACTERIAL-DNA;

D O I：

10.1586/14760584.2014.863715

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CpG Oligonucleotides (ODN) are immunomodulatory synthetic oligonucleotides designed to specifically agonize Toll-like receptor 9. Here, we review recent progress in understanding the mechanism of action of CpG ODN and provide an overview of human clinical trial results using CpG ODN to improve the vaccines for cancer, allergy and infectious disease.

引用

页码：299 / 312

页数：14

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