Synthesis of aminoglycoside-DNA conjugates

被引：47

作者：

Charles, I ^{[1
]}

Xue, LA ^{[1
]}

Arya, DP ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem, Lab Med Chem, Clemson, SC 29634 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 09期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(02)00157-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1259 / 1262

页数：4

共 26 条

[1] Aminoglycoside-nucleic acid interactions: Remarkable stabilization of DNA and RNA triple helices by neomycin [J].

Arya, DP ;

Coffee, RL ;

Willis, B ;

Abramovitch, AI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (23) :5385-5395

[2] Neomycin-induced hybrid triplex formation [J].

Arya, DP ;

Coffee, RL ;

Charles, I .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (44) :11093-11094

[3] DNA triple helix stabilization by aminoglycoside antibiotics [J].

Arya, DP ;

Coffee, RL .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (17) :1897-1899

[4] SOLID-PHASE SYNTHESIS OF OLIGODEOXYNUCLEOTIDES CONTAINING PHOSPHORAMIDATE INTERNUCLEOTIDE LINKAGES AND THEIR SPECIFIC CHEMICAL CLEAVAGE [J].

BANNWARTH, W .

HELVETICA CHIMICA ACTA, 1988, 71 (06) :1517-1527

[5] Specificity in the binding of aminoglycosides to HIV-RRE RNA [J].

Cho, JH ;

Rando, RR .

BIOCHEMISTRY, 1999, 38 (26) :8548-8554

[6] A structural basis for RNA-ligand interactions [J].

Chow, CS ;

Bogdan, FM .

CHEMICAL REVIEWS, 1997, 97 (05) :1489-1513

[7] Aminoglycoside antibiotics [J].

Forge, A ;

Schacht, J .

AUDIOLOGY AND NEURO-OTOLOGY, 2000, 5 (01) :3-22

[8] Antimicrobial cycling: Lessons learned from the aminoglycoside experience [J].

Gerding, DN .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2000, 21 (01) :S12-S17

[9] Minimal RNA constructs that specifically bind aminoglycoside antibiotics with high affinities [J].

Hamasaki, K ;

Killian, J ;

Cho, JY ;

Rando, RR .

BIOCHEMISTRY, 1998, 37 (02) :656-663

[10] Specific binding of aminoglycosides to a human rRNA construct based on a DNA polymorphism which causes aminoglycoside-induced deafness [J].

Hamasaki, K ;

Rando, RR .

BIOCHEMISTRY, 1997, 36 (40) :12323-12328

← 1 2 3 →