Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

被引：397

作者：

Bernal, M. A. ^{[1
]}

Bordage, M. C. ^{[2
,3
]}

Brown, J. M. C. ^{[4
,5
]}

Davidkova, M. ^{[6
]}

Delage, E. ^{[7
]}

El Bitar, Z. ^{[8
]}

Enger, S. A. ^{[9
]}

Francis, Z. ^{[10
]}

Guatelli, S. ^{[11
]}

Ivanchenko, V. N. ^{[12
,13
]}

Karamitros, M. ^{[14
]}

Kyriakou, I. ^{[15
]}

Maigne, L. ^{[7
]}

Meylan, S. ^{[16
]}

Murakami, K. ^{[17
]}

Okada, S. ^{[17
]}

Payno, H. ^{[7
]}

Perrot, Y. ^{[7
]}

Petrovic, I. ^{[18
]}

Pham, Q. T. ^{[7
]}

Ristic-Fira, A. ^{[18
]}

Sasaki, T. ^{[17
]}

Stepan, V. ^{[6
]}

Tran, H. N. ^{[19
,20
]}

Villagrasa, C. ^{[16
]}

Incerti, S. ^{[19
,20
,21
,22
]}

机构：

[1] Univ Estadual Campinas, Inst Fis Gleb Wataghin, BR-13081970 Campinas, SP, Brazil

[2] Univ Toulouse 3, CRCT, UMR 1037, INSERM, F-31062 Toulouse, France

[3] Univ Toulouse III Paul Sabatier, UMR 1037, CRCT, F-31000 Toulouse, France

[4] Monash Univ, Sch Phys & Astron, Melbourne, Vic 3004, Australia

[5] Queens Univ Belfast, Sch Math & Phys, Belfast BT7 1NN, Antrim, North Ireland

[6] CAS, Dept Radiat Dosimetry, Inst Nucl Phys, Prague, Czech Republic

[7] Clermont Univ, CNRS, IN2P3, Lab Phys Corpusculaire, Aubiere, France

[8] Inst Pluridisciplinaire Hubert Curien, Strasbourg, France

[9] McGill Univ, Dept Oncol, Med Phys Unit, Montreal, PQ, Canada

[10] Uni St Jeseph, Dept Phys, Fac Sci, Beirut, Lebanon

[11] Univ Wollongong, Ctr Med Radiat Phys, Wollongong, NSW 2522, Australia

[12] Geant4 Associates Int Ltd, Hebden Bridge, W Yorkshire, England

[13] Ecoanalytica, Moscow 119899, Russia

[14] Univ Notre Dame, Notre Dame Radiat Lab, Notre Dame, IN 46556 USA

[15] Univ Ioannina, Sch Med, Med Phys Lab, GR-45110 Ioannina, Greece

[16] IRSN, BP17, F-92962 Fontenay Aux Roses, France

[17] Natl Lab High Energy Phys, KEK, Tsukuba, Ibaraki 305, Japan

[18] Univ Belgrade, Vinca Inst Nucl Sci, Belgrade, Serbia

[19] Ton Duc Thang Univ, Div Nucl Phys, Ho Chi Minh City, Vietnam

[20] Ton Duc Thang Univ, Fac Sci Appl, Ho Chi Minh City, Vietnam

[21] Univ Bordeaux, CENBG, UMR 5797, F-33170 Gradignan, France

[22] CNRS, IN2P3, CENBG, UMR 5797, F-33170 Gradignan, France

来源：

PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS | 2015年 / 31卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

Monte Carlo; Geant4-DNA; Radiolysis; Radiobiology; Ionizing radiation; INELASTIC CROSS-SECTIONS; QUANTITATIVE MODEL; ELECTRON-TRANSPORT; STOCHASTIC-MODELS; PHYSICS PROCESSES; DNA-DAMAGE; S-VALUES; PROTON; MICRODOSIMETRY; DEPOSITION;

D O I：

10.1016/j.ejmp.2015.10.087

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of today's radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described. (C) 2015 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

引用

页码：861 / 874

页数：14

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