Conjugated Polymer Nanoparticles with Absorption beyond 1000 nm for NIR-II Fluorescence Imaging System Guided NIR-II Photothermal Therapy

被引：61

作者：

Song, Xingwen ^{[1
,2
]}

Lu, Xiaomei ^{[1
,2
]}

Sun, Bo ^{[3
,4
]}

Zhang, Hua ^{[3
,4
]}

Sun, Pengfei ^{[3
,4
]}

Miao, Han ^{[7
]}

Fan, Quli ^{[3
,4
]}

Huang, Wei ^{[5
,6
]}

机构：

[1] Nanjing Tech Univ NanjingTech, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Key Lab Flexible Elect KLOFE, Nanjing 211816, Peoples R China

[2] Nanjing Tech Univ NanjingTech, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Nanjing 211816, Peoples R China

[3] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China

[4] Nanjing Univ Posts & Telecommun, Inst Adv Mat Jam, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China

[5] Northwestern Polytech Univ, Frontiers Sci Ctr Flexible Elect FSCFE, Xian 710072, Peoples R China

[6] Northwestern Polytech Univ, Shaanxi Inst Flexible Elect SIFE, Xian 710072, Peoples R China

[7] Inst Basic Sci IBS, Ctr Soft & Living Matter, Ulsan 44919, South Korea

来源：

ACS APPLIED POLYMER MATERIALS | 2020年 / 2卷 / 10期

基金：

中国国家自然科学基金;

关键词：

NIR-II fluorescence imaging; NIR-II photothermal therapy; conjugated polymer; signal-to-background ratio; antitumor; DOTS; WINDOW;

D O I：

10.1021/acsapm.0c00637

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The second near-infrared fluorescence imaging (NIR-II FI) guided NIR-II photothermal therapy (PTT) possesses advantages for cancer treatment because of its accurate diagnosis and enhanced therapeutic effects for cancer. However, developing a conjugated polymer with both excellent NIR-II fluorescence and NIR-II PTT properties encountered many hindrances, including strong nonradiative decay, low solubility in organic solution, and significant aggregation-caused quenching (ACQ) effect. Herein, a conjugated polymer TTQ-2TC with optimized absorption in NIR-II regions, good solubility in organic solvents, and bright NIR-II FI signals is obtained through introducing the alkyl-side-chain-modified bithiophene (2TC) as the electronrich donor unit. The water-soluble nanoparticle (TTQ-2TC NPs) prepared from the conjugated polymer TTQ-2TC is used for precise NIR-II FI guided NIR-II PTT treatment. The in vivo blood and tumor imaging and therapy results show that the TTQ-2TC NPs possess high signal-to-background ratio (SBR) and perfect antitumor efficacy by NIR-II PTT.

引用

页码：4171 / 4179

页数：9

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