Space-dependent perfusion coefficient estimation in a 2D bioheat transfer problem

In this work, a method for estimating the space-dependent perfusion coefficient parameter in a 2D bioheat transfer model is presented. In the method, the bioheat transfer model is transformed into a time-dependent semidiscrete system of ordinary differential equations involving perfusion coefficient values as parameters, and the estimation problem is solved through a nonlinear least squares technique. In particular, the bioheat problem is solved by the method of lines based on a highly accurate pseudospectral approach, and perfusion coefficient values are estimated by the regularized Gauss Newton method coupled with a proper regularization parameter. The performance of the method on several test problems is illustrated numerically. (C) 2017 Elsevier B.V. All rights reserved.