Functional oligopeptide as a novel strategy for drug delivery

被引：20

作者：

Ji, Yujie ^{[1
]}

Qiao, Hongzhi ^{[1
]}

He, Jiayu ^{[1
]}

Li, Weidong ^{[1
]}

Chen, Rui ^{[1
]}

Wang, Jingjing ^{[1
]}

Wu, Li ^{[1
]}

Hu, Rongfeng ^{[2
]}

Duan, Jinao ^{[1
]}

Chen, Zhipeng ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Dept Pharm, Nanjing, Jiangsu, Peoples R China

[2] Anhui Univ Chinese Med, Dept Pharm, Hefei, Anhui, Peoples R China

来源：

JOURNAL OF DRUG TARGETING | 2017年 / 25卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Oligopeptide; stimuli-responsive; self-assemble; targeting; functional; PEPTIDE; TUMOR; NANOPARTICLES; DOXORUBICIN; LIPOSOMES; CANCER; ASSEMBLIES; EFFICACY;

D O I：

10.1080/1061186X.2017.1309044

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oligopeptides, a type of short peptide, which consist of 2-20 amino acids, exhibit a variety of biological functions in drug delivery systems, such as specific targeting, cell penetration, self-assembled capacity and responsiveness to the environment. In this review, we aim to highlight the importance of functional oligopeptides for nanomedical applications and put forward the views on the future development direction of oligopeptide medicines. Oligopeptides have gained wide attentions due to their inherent properties, but the lack of understanding the mechanisms of in vivo transport behavior is the biggest problem and challenge at the present stage. Therefore, it is an important direction for the future clinical research to systematically evaluate its metabolic behavior and safety in vivo.

引用

页码：597 / 607

页数：11

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