Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice

被引：26

作者：

Abraham, RS ^{[1
]}

David, CS ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Sch Med, Dept Immunol, Rochester, MN 55905 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2000年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(99)00060-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has seen a spate of research in the use of HLA transgenic mice in the identification of self antigens associated with autoimmunity. Dominant T cell determinants - and, in a few cases, B cell determinants - have been characterized in the context of disease-predisposing HLA DR and DQ genes for at least three prominent and devastating autoimmune diseases: rheumatoid arthritis, multiple sclerosis and insulin-dependent diabetes mellitus.

引用

页码：122 / 129

页数：8

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