Nanosuspensions: a promising drug delivery strategy

被引:654
作者
Patravale, VB [1 ]
Date, AA
Kulkarni, RM
机构
[1] Univ Inst Chem Technol, Div Pharmaceut, Bombay 400019, Maharashtra, India
[2] Bombay Coll Pharm, Dept Pharmaceut, Bombay 400098, Maharashtra, India
[3] Univ Cincinnati, Dept Cell Biol Neurobiol & Anat, Med Ctr, Cincinnati, OH 45267 USA
关键词
D O I
10.1211/0022357023691
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Nanosuspensions have emerged as a promising strategy for the efficient delivery of hydrophobic drugs because of their versatile features and unique advantages. Techniques such as media milling and high-pressure homogenization have been used commercially for producing nanosuspensions. Recently, the engineering of nanosuspensions employing emulsions and microemulsions as templates has been addressed in the literature. The unique features of nanosuspensions have enabled their use in various dosage forms, including specialized delivery systems such as mucoadhesive hydrogels. Rapid strides have been made in the delivery of nanosuspensions by parenteral, peroral, ocular and pulmonary routes. Currently, efforts are being directed to extending their applications in site-specific drug delivery.
引用
收藏
页码:827 / 840
页数:14
相关论文
共 96 条
[1]   TUMORICIDAL ACTIVITY OF KUPFFER CELLS AUGMENTED BY ANTICANCER DRUGS [J].
ADACHI, Y ;
ARII, S ;
FUNAKI, N ;
HIGASHITSUJI, H ;
FUJITA, S ;
FURUTANI, M ;
MISE, M ;
ZHANG, WH ;
TOBE, T .
LIFE SCIENCES, 1992, 51 (03) :177-183
[2]   Excipient-drug interactions in parenteral formulations [J].
Akers, MJ .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2002, 91 (11) :2283-2300
[3]   Liposomes - Opportunities in drug delivery [J].
Allen, TM .
DRUGS, 1997, 54 (Suppl 4) :8-14
[4]  
Aungst B., 1994, BT GATTEFOSSE, V87, P49
[5]  
Aungst BJ, 2000, J PHARM SCI, V89, P429, DOI 10.1002/(SICI)1520-6017(200004)89:4<429::AID-JPS1>3.0.CO
[6]  
2-J
[8]   Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery [J].
Benet, LZ ;
Izumi, T ;
Zhang, YC ;
Silverman, JA ;
Wacher, VJ .
JOURNAL OF CONTROLLED RELEASE, 1999, 62 (1-2) :25-31
[9]   PHYSICOCHEMICAL ASPECTS OF DRUG RELEASE .8. THE RELATION BETWEEN PARTICLE-SIZE AND SURFACE SPECIFIC DISSOLUTION RATE IN AGITATED SUSPENSIONS [J].
BISRAT, M ;
NYSTROM, C .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 47 (1-3) :223-231
[10]  
Blunk T, 1996, EUR J PHARM BIOPHARM, V42, P262