Langerhans cell migration is modulated by N-sulfated glucosamine moieties in heparin

被引：10
作者：
O'Sullivan, GM [1 ]
Boswell, CM [1 ]
Halliday, GM [1 ]
机构：
[1] Univ Sydney, Royal Prince Alfred Hosp, Dept Med Dermatol, Sydney, NSW 2006, Australia
来源：
EXPERIMENTAL DERMATOLOGY | 2000年 / 9卷 / 01期
关键词：
Langerhans cell; dendritic cell; leucocyte migration; glycosaminoglycan;
D O I：
10.1034/j.1600-0625.2000.009001025.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Dendritic cell (DC) migration into and out of tissues is important for the generation of primary immune responses to antigens encountered in tissues. In order to study the mechanisms involved in DC migration we used a skin explant system and quantitated the number of Langerhans cells (LC), which are immature precursors of DC in skin-draining lymph nodes, remaining in the epidermis in response to incubation with various biomolecules. This paper shows that LC trafficking in epidermis is a metabolically active process that is modulated by heparin, specifically by N-sulfated glucosamine moieties in heparin. This is the first demonstration of structural specificity in the biochemical requirements for DC migration in a tissue and therefore is important to understanding DC migration in general.
引用
收藏
页码：25 / 33
页数：9
相关论文
共 41 条
12345