Psychophysiological effects of an iTBS modulated virtual reality challenge including participants with spider phobia

被引：48

作者：

Notzon, S. ^{[1
]}

Deppermann, S. ^{[2
]}

Fallgatter, A. ^{[2
,3
,4
]}

Diemer, J. ^{[5
]}

Kroczek, A. ^{[2
,6
]}

Domschke, K. ^{[7
]}

Zwanzger, P. ^{[1
,8
,9
]}

Ehlis, A. -C. ^{[2
]}

机构：

[1] Univ Munster, Dept Psychiat, Mood & Anxiety Disorders Res Unit, D-48149 Munster, Germany

[2] Univ Tubingen, Dept Psychiat & Psychotherapy, D-72076 Tubingen, Germany

[3] Univ Tubingen, Grad Sch LEAD, D-72072 Tubingen, Germany

[4] Univ Tubingen, Cluster Excellence CIN, D-72076 Tubingen, Germany

[5] Univ Regensburg, Dept Psychol Clin Psychol & Psychotherapy, D-93053 Regensburg, Germany

[6] IMPRS Cognit & Neurosci, D-72076 Tubingen, Germany

[7] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, D-97080 Wurzburg, Germany

[8] Kbo Inn Salzach Hosp, D-83512 Wasserburg, Germany

[9] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany

来源：

BIOLOGICAL PSYCHOLOGY | 2015年 / 112卷

关键词：

Anxiety disorders; Heart rate (HR); Heart rate variability (HRV); iTBS; Skin conductance level (SCL); Specific phobia; Spider phobia; Theta burst stimulation; Transcranial magnetic stimulation (TMS); Virtual reality (VR); TRANSCRANIAL MAGNETIC STIMULATION; HEART-RATE-VARIABILITY; THETA-BURST STIMULATION; MAJOR DEPRESSION; ANXIETY DISORDERS; PREFRONTAL CORTEX; PANIC DISORDER; EXPOSURE; AMYGDALA; FEAR;

D O I：

10.1016/j.biopsycho.2015.10.003

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Preliminary evidence suggests beneficial effects of transcranial magnetic stimulation (TMS) on anxiety. The objective of this study was to investigate the effects of intermittent theta burst stimulation (iTBS) as a form of TMS on acute anxiety provoked by a virtual reality (VR) scenario. Participants with spider phobia (n = 41) and healthy controls (n = 42) were exposed to a spider scenario in VR after one session of iTBS over the prefrontal cortex or sham treatment. Participants with spider phobia reacted with more anxiety compared to healthy controls. Their heart rate and skin conductance increased compared to baseline. Contrary to expectations, iTBS did not influence these reactions, but modulated heart rate variability (HRV). Sympathetic influence on HRV showed an increase in the active iTBS group only. This study does not support the idea of beneficial effects of a single session of iTBS on anxiety, although other protocols or repeated sessions might be effective. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：66 / 76

页数：11

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