In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene

被引：68
作者：
Figueiredo, Samy [1 ,2 ]
Poirel, Laurent [1 ,2 ]
Croize, Jacques [3 ]
Recule, Christine [3 ]
Nordmann, Patrice [1 ,2 ]
机构：
[1] Hop Bicetre, AP HP, Serv Bacteriol Virol,Fac Med, INSERM,U Emerging Resistance Antibiot 914, K Bicetre, France
[2] Univ Paris 11, K Bicetre, France
[3] DAI Pol Biol, Dept Bacteriol Microbiovigilance, Grenoble, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期
关键词：
HYDROLYZING OXACILLINASES; RESISTANCE; ISABA1; EXPRESSION; EMERGENCE; INSERTION; OUTBREAK;
D O I：
10.1128/AAC.01663-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla(OXA-66) gene.
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收藏
页码：2657 / 2659
页数：3
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