The host targeting effect of chloroquine in malaria

被引：49

作者：

Coban, Cevayir ^{[1
,2
]}

机构：

[1] Univ Tokyo, Inst Med Sci IMSUT, Div Malaria Immunol, Dept Microbiol & Immunol, Tokyo, Japan

[2] Osaka Univ, Immunol Frontier Res Ctr IFReC, Lab Malaria Immunol, Osaka, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2020年 / 66卷

基金：

日本科学技术振兴机构;

关键词：

PLASMODIUM-FALCIPARUM; ANTIMALARIAL-DRUGS; CELLS; ARTEMISININ; RESISTANCE; INFECTION; HEMOZOIN; DEGRADATION; INHIBITION; MECHANISMS;

D O I：

10.1016/j.coi.2020.07.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Due to the rapid onset and spread of the COVID-19 pandemic, the treatment of COVID-19 patients by hydroxychloroquine alone or in combination with other drugs has captured a great deal of attention and triggered considerable debate. Historically, the worldwide use of quinoline based-drugs has led to a spectacular reduction in death from malaria. Unfortunately, scientists have been forced to seek alternative drugs to treat malaria due to the emergence of chloroquineresistant parasites in the 1960s. The repurposing of hydroxychloroquine against viral infections, various types of cancer and autoimmune diseases has been ongoing for more than 70 years, with no clear understanding of its mechanism of action (MOA). Here, we closely examine the MOA of this old but influential drug in and beyond malaria. Better insights into how chloroquine targets the host's cellular and immune responses may help to develop applications against to new pathogens and diseases, and perhaps even restore the clinical utility of chloroquine against malaria.

引用

页码：98 / 107

页数：10

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