A Smart "Sense-Act-Treat" System: Combining a Ratiometric pH Sensor with a Near Infrared Therapeutic Gold Nanocage

被引：87

作者：

Shi, Peng ^{[1
]}

Liu, Zhen ^{[1
]}

Dong, Kai ^{[1
]}

Ju, Enguo ^{[1
]}

Ren, Jinsong ^{[1
]}

Du, Yingda ^{[2
]}

Li, Zhengqiang ^{[2
]}

Qu, Xiaogang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Lab Chem Biol,Univ Chinese Acad Sci, Div Biol Inorgan Chem,State Key Lab Rare Earth Re, Changchun 130022, Jilin, Peoples R China

[2] Jilin Univ, Coll Life Sci, Changchun 130021, Jilin, Peoples R China

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 38期

关键词：

theranostics; nanomedicine; ratiometry; gold nanocage; NIR; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; INTRACELLULAR PH; CONTROLLED-RELEASE; DRUG-DELIVERY; PLATFORM; PROBE; EMISSION; CELL; NANOCARRIERS;

D O I：

10.1002/adma.201402522

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we design a "sense-act-treat" system via the combination of a ratiometric pH sensor with a therapeutic gold nanocage. Our design could "sense" the tumor through two-state switching of fluorescence and further provide chemotherapy and hyperthermia for "treating" the tumor, showing the potential for future biomedical applications. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6635 / 6641

页数：7

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