Cellular signaling in the aging immune system

被引：106

作者：

Fulop, Tamas ^{[1
]}

Le Page, Aurelie ^{[1
]}

Fortin, Carl ^{[1
]}

Witkowski, Jacek M. ^{[2
]}

Dupuis, Gilles ^{[3
]}

Larbi, Anis ^{[4
]}

机构：

[1] Univ Sherbrooke, Fac Med & Hlth Sci, Grad Program Immunol, Res Ctr Aging,Dept Med, Sherbrooke, PQ J1K 2R1, Canada

[2] Med Univ Gdansk, Dept Pathophysiol, Gdansk, Poland

[3] Univ Sherbrooke, Fac Med & Hlth Sci, Grad Program Immunol, Dept Biochem, Sherbrooke, PQ J1K 2R1, Canada

[4] ASTAR, Singapore Immunol Network SIgN, Singapore 138648, Singapore

来源：

CURRENT OPINION IN IMMUNOLOGY | 2014年 / 29卷

基金：

加拿大健康研究院;

关键词：

PROTEIN-TYROSINE PHOSPHATASES; LOW-GRADE INFLAMMATION; AGE-RELATED-CHANGES; T-CELL; LIPID RAFTS; MOLECULAR-MECHANISMS; DOWN-REGULATION; MEMBRANE RAFTS; FREE-RADICALS; SHP-1;

D O I：

10.1016/j.coi.2014.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Causes for immunosenescence and inflamm-aging have to be established. Efficient function of the immune system requires homeostatic regulation from receptor recognition of antigenic challenge to cell responses and adaptation to its changing environment. It is reasonable to assume that one of the most important molecular causes of immunosenescence is alteration in the regulation of signaling pathways. Indeed, alterations in feed-forward and negative feedback (inhibitory) signaling have been highlighted in all cells involved in the immune response including short-lived (neutrophils) and long-lived (T lymphocytes) cells. These dysregulations tip the balance in favor of altered (less efficient) function of the immune system. In this review, we summarize our knowledge on signal transduction changes in the aging immune system and propose a unifying mechanism as one of the causes of immunosenescence. Modulation of these pathways with aging represents a major challenge to restore the immune response to functional levels.

引用

页码：105 / 111

页数：7

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