Recalling happy memories in remitted depression: A neuroimaging investigation of the repair of sad mood

被引:30
作者
Foland-Ross, Lara C. [1 ,3 ]
Cooney, Rebecca E. [1 ]
Joormann, Jutta [2 ]
Henry, Melissa L. [1 ]
Gotlib, Ian H. [1 ]
机构
[1] Stanford Univ, Stanford, CA 94305 USA
[2] Univ Miami, Miami, FL USA
[3] Stanford Univ, Dept Psychol, Stanford Mood & Anxiety Disorders Lab, Stanford, CA 94305 USA
关键词
Ventral prefrontal cortex; Depression; Affect; Mood; Emotion regulation; fMRI; Autobiographical memory; VENTROLATERAL PREFRONTAL CORTEX; AUTOBIOGRAPHICAL MEMORY; COGNITIVE CONTROL; BRAIN ACTIVITY; INHIBITION; FMRI;
D O I
10.3758/s13415-013-0216-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Major depressive disorder (MDD) is a recurrent mood disorder. The high rate of recurrence of MDD suggests the presence of stable vulnerability factors that place individuals with a history of major depression at an increased risk for the onset of another episode. Previous research has linked the remitted state, and therefore increased vulnerability for depressive relapse, with difficulties in the use of pleasant autobiographical memories to repair sad mood. In the present study, we examined the neural correlates of these difficulties. Groups of 16 currently euthymic, remitted depressed individuals and 16 healthy (control) women underwent functional magnetic resonance imaging (fMRI) during sad mood induction and during recovery from a sad mood state through recall of mood-incongruent positive autobiographical memories. Sad mood was induced in participants by using film clips; participants then recalled positive autobiographical memories, a procedure previously shown to repair negative affect. During both the sad mood induction and automatic mood regulation, control participants exhibited activation in the left ventrolateral prefrontal cortex (vlPFC) and cuneus; in contrast, remitted participants exhibited a decrease in activation in these regions. Furthermore, exploratory analyses revealed that reduced activation levels during mood regulation predicted a worsening of depressive symptoms at a 20-month follow-up assessment. These findings highlight a dynamic role of the vlPFC and cuneus in the experience and modulation of emotional states and suggest that functional anomalies of these brain regions are associated with a history of, and vulnerability to, depression.
引用
收藏
页码:818 / 826
页数:9
相关论文
共 41 条
  • [1] Left ventrolateral prefrontal cortex and the cognitive control of memory
    Badre, David
    Wagner, Anthony D.
    [J]. NEUROPSYCHOLOGIA, 2007, 45 (13) : 2883 - 2901
  • [2] Beck A.T., 1996, Manual for the BDI-II, DOI DOI 10.1037/T00742-000
  • [3] Boland R.J., 2009, HDB DEPRESSION, V2nd, P23
  • [4] Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample
    Brown, TA
    Campbell, LA
    Lehman, CL
    Grisham, JR
    Mancill, RB
    [J]. JOURNAL OF ABNORMAL PSYCHOLOGY, 2001, 110 (04) : 585 - 599
  • [5] Cognitive Reappraisal of Emotion: A Meta-Analysis of Human Neuroimaging Studies
    Buhle, Jason T.
    Silvers, Jennifer A.
    Wager, Tor D.
    Lopez, Richard
    Onyemekwu, Chukwudi
    Kober, Hedy
    Weber, Jochen
    Ochsner, Kevin N.
    [J]. CEREBRAL CORTEX, 2014, 24 (11) : 2981 - 2990
  • [6] Amygdala reactivity to emotional faces predicts improvement in major depression
    Canli, T
    Cooney, RE
    Goldin, P
    Shah, M
    Sivers, H
    Thomason, ME
    Whitfield-Gabrieli, S
    Gabrieli, JDE
    Gotlib, IH
    [J]. NEUROREPORT, 2005, 16 (12) : 1267 - 1270
  • [7] The precuneus and consciousness
    Cavanna, Andrea E.
    [J]. CNS SPECTRUMS, 2007, 12 (07) : 545 - 552
  • [8] Remembering the good times:: neural correlates of affect regulation
    Cooney, Rebecca E.
    Joormann, Jutta
    Atlas, Lauren Y.
    Eugene, Fanny
    Gotlib, Ian H.
    [J]. NEUROREPORT, 2007, 18 (17) : 1771 - 1774
  • [9] AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
    Cox, RW
    [J]. COMPUTERS AND BIOMEDICAL RESEARCH, 1996, 29 (03): : 162 - 173
  • [10] Subcortical and cortical brain activity during the feeling of self-generated emotions
    Damasio, AR
    Grabowski, TJ
    Bechara, A
    Damasio, H
    Ponto, LLB
    Parvizi, J
    Hichwa, RD
    [J]. NATURE NEUROSCIENCE, 2000, 3 (10) : 1049 - 1056