Analysis of COI and ITS2 regions of DNA obtained from Paragonimus westermani eggs in ancient coprolites on Joseon dynasty mummies

被引：4
作者：
Hong, Jong Ha [1 ]
Oh, Chang Seok [1 ,2 ]
Seo, Min [3 ]
Shin, Dong Hoon [1 ,2 ]
机构：
[1] Seoul Natl Univ, Lab Bioanthropol Paleopathol & Hist Dis, Coll Med, Seoul, South Korea
[2] Seoul Natl Univ, Inst Forens Sci, Coll Med, Seoul, South Korea
[3] Dankook Univ, Dept Parasitol, Coll Med, Cheonan, South Korea
来源：
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2019年 / 114卷
关键词：
ancient parasite; Paragonimus westermani; ancient DNA; SUBSTITUTIONS; INFECTION; PEOPLE;
D O I：
10.1590/0074-02760180595
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The genetic information of ancient Paragonimus westermani, the oriental lung fluke infecting over 20 million people worldwide, has not been thoroughly investigated thus far. We analysed genetic markers (COI and ITS2) of P. westermani from coprolite specimens (n = 6) obtained from 15th to 18th century Korean mummies. Our results indicated that all P. westermani sequences were generally distinct from the other species of the genus Paragonimus. The sequences were clustered into three groups: Group I for East Asia; Group II for South and Southeast Asia; and Group III for India and Sri Lanka. In this study, we found that ancient P. westermani sequences in Korea belong to Group I, adding invaluable information to the existing knowledge of Paragonimus paleogenetics.
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页数：6
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