Enantioselective Friedel-Crafts alkylation for synthesis of 2-substituted indole derivatives

被引：68

作者：

Zhang, Yulong ^{[1
]}

Liu, Xiaohua ^{[1
]}

Zhao, Xiaohu ^{[1
]}

Zhang, Jianlin ^{[1
]}

Zhou, Lin ^{[1
]}

Lin, Lili ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Coll Chem, Chengdu 610064, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 96期

基金：

中国国家自然科学基金;

关键词：

CHIRAL BRONSTED ACIDS; ASYMMETRIC-SYNTHESIS; 4,7-DIHYDROINDOLES; CYCLIZATION; CASCADE; PYRROLOINDOLINES; ANNULATION; ALKALOIDS; CATALYSIS; ESTERS;

D O I：

10.1039/c3cc45665j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient catalytic asymmetric intermolecular C2 Friedel-Crafts alkylation reaction between N-methyl skatole and beta,gamma-unsaturated alpha-ketoesters has been realized by a chiral N,N'-dioxide-Ni(II) complex. The corresponding indole derivatives were obtained in good yield (up to 96%) with excellent enantioselectivities (up to 99% ee) under mild reaction conditions.

引用

收藏

页码：11311 / 11313

页数：3

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